| FRIDAY, OCTOBER 15 |
|
| Opening Reception, Keynote Speakers |
|
| Brian Druker,
Oregon Health & Science University |
Lessons from hematologic malignancy |
| Meenhard Herlyn, University of Pennsylvania |
Cell-cell communications for melanocytes and melanoma
cells |
| |
|
| SATURDAY, OCTOBER 16 |
|
| Breakfast |
|
| Neil
Swanson, Oregon Health & Science University; Molly Kulesz-Martin,
Oregon Health & Science University; Jackie Bickenbach, University
of Iowa |
Welcome
and Introductions |
| |
|
| Multi-Stage Carcinogenesis |
|
| John DiGiovanni, UT MD Anderson Cancer Center |
The role of Stat3 in carcinogenesis |
| James G. Rheinwald, Harvard Medical School |
Co-expression of p16INK4A and laminin 5 gamma 2 in keratinocytes:
a normal wound healing response that goes awry during neoplastic
progression to carcinoma |
| Claudio Conti, UT MD Anderson Cancer Center |
Cell cycle regulation and skin tumorigenesis: Lessons from
genetically-engineered mice |
| Glenn Merlino, National Cancer Institute |
Creating UV responsive, genetically tractable mouse models
of cutaneous melanoma |
| Coffee Break |
|
| Petra Boukamp, German Cancer Research Center |
The role of Telomerase- and telomeres in normal epidermis and
carcinogenesis |
| Jack Longley, University of Wisconsin |
Keratinocyte SCF and melanocyte KIT signalling |
| Neil F. Box, Baylor College of Medicine |
The Sooty Foot Ataxia mouse: A new model for p53 pathway melanoma? |
| David Greenhalgh, Glasgow University |
Inducible
cre-mediated N-ras activation and PTEN inactivation in transgenic
mouse epidermal keratinocytes elicits melanocyte hyperplasia
in papillomas |
| Lunch
Break |
|
| |
|
| Basal Cell/Metabolic Paths |
|
| Andrzej Dlugosz, University of Michigan |
Hedgehog signaling requirements in hair follicles and basal
cell carcinomas |
| Rune Toftgård,
Karolinska Institute |
NFkB pathway in epidermal cell carcinoma |
| Marcel Huber, Lausanne University |
The tumor suppressor CYLD interacts with TRIP and regulates
negatively NF-kB activation by cytokines |
| Coffee Break |
|
| Susan M. Fischer, UT MD Anderson Cancer Center |
Are prostaglandins necessary for skin cancer development? |
| Tatiana M. Oberyszyn, The Ohio State University |
Immunosuppression, inflammation and skin cancer |
| Stephen E. Ulrich, UT MD Anderson Cancer Center |
A role for Platelet activating factor receptor binding in UV-induced
immune suppression and skin cancer induction |
| Richard Eckert, Case School of Medicine |
PKCd regulates keratinocyte death and survival by regulating
activity and subcellular localization of a p38d-ERK1/2 complex |
| Ajit K. Verma, University of Wisconsin |
Tumor necrosis factor a is linked to the susceptibility of
protein kinase C e transgenic mice to ultraviolet radiation-induced
cutaneous damage and development of squamous cell carcinomas |
| Mitchell F. Denning, Loyola University Medical Center |
Regulation of melanoma growth by protein kinase C isoforms |
| |
|
| Announcements |
|
| Break |
|
| Banquet
Dinner: Neil Swanson, MD, Oregon Health & Science University |
Introductions
and Thank you's |
Banquet
Dinner: Albert M. Kligman, MD, PhD, Foundation for Basic Cutaneous
Research |
Bill
Montagna and the shaping of dermatology through the Montagna
Symposium |
| Banquet
Dinner: Fran
Storrs, MD, Oregon Health & Science University |
John Storrs and the building of Salishan Lodge:
A remembrance |
| |
|
| SUNDAY, OCTOBER 17 |
|
| Breakfast |
|
| Coastal
hills hike – or
optional free time |
| Lunch
Break |
|
| |
|
| Intra-Intercellular Signalling |
|
| Brian J. Nickoloff, Loyola University Medical Center |
Role of notch signaling in melanoma pathogenesis and treatment |
| Stuart Yuspa, National Cancer Institute |
CLIC4, an intracellular chloride channel protein, is a novel
molecular target for cancer therapy |
| Steven
L. Jacques, Oregon Health & Science University |
Optical imaging of skin using confocal microscopy,
optical coherence tomography and a polarized light camera |
| Barbara
Bedogni,
Stanford University |
Akt and Hypoxia synergize in transforming melanocytes: role
of the translation initiation machinery and HIF1a |
| Coffee
Break |
|
| Anne E. Cress, Stanford University |
Disruption of a delicate balance: Integrin clipping during
human tumor progression |
| Rosemary J. Akhurst, UCSF Comprehensive Cancer
Center |
Genetic interactions between Tgfb1 and Tgfbm3
contribute to risk of skin cancer in mice |
| Adam Glick, National Cancer Institute |
Benign and malignant mouse epidermal squamous tumors have discordant
transcriptional responses to TGFb1 in vivo |
| Xiao-Jing
Wang, Oregon Health & Science University |
The role of TGFb1 on skin inflammation: Implication in skin
cancer promotion |
| |
|
| Jackie Bickenbach, University of Iowa |
2004
Farber Awards presentation |
| Poster Session/Reception |
Ervin Epstein, Andrew Blauvelt, guides |
| |
|
| MONDAY,
OCTOBER 18 |
|
| Breakfast |
|
| |
|
| Growth/Differentiation/Apoptosis/p53 |
|
| Jingwu Xie, UT Medical Branch at Galveston |
Inhibition of Smoothened Signaling Prevents Ultraviolet B (UVB)-Induced
Basal Cell Carcinomas through Regulation of Fas Expression and
Apoptosis |
| Hua Lu,
Oregon Health & Science University |
SSRP1 regulates TAp63 functions |
| Wendy Weinberg,
Food & Drug Administration |
p63
isotype roles in epidermal homeostasis |
| Maria S. Soengas, University of Michigan |
Rational design of novel small molecules that shift the mode
of action of mapk inhibitors from cell cycle arrest to apoptosis
in aggressive melanoma cells |
| Mihail
Iordanov, Oregon Health & Science University |
Apoptotic
keratinocytes secrete mitogenic factors: Implications for eczemas
and cancer |
| Coffee
Break |
|
| Dennis Roop, Baylor College of Medicine |
Genes which alter stem cell fate or commitment to a stratified
epithelial lineage influence susceptibility to skin cancer and
tumor phenotype |
| Frank McKeon, Harvard Medical School |
Role of p63 in the maintenance of epidermal progenitor cells |
| Lunch
Break |
|
| |
|
| Prevention |
|
| Zigang
Dong, University of Minnesota |
JNK
and skin carcinogenesis |
| Connie
B. Lin, J&J CPPW Skin Research Center |
The
inhibitory effect of topical applications of non-denatured
soy extracts on UVB-induced erythema, DNA damage, and apoptosis,
and on the formation and growth of skin tumors |
| Jill
C. Pelling, Northwestern University School of Medicine |
UVB-induced
COX-2 transcription in mouse keratinocytes requires the Ebox,
ATF/CRE and NF-IL6 responsive elements and is inhibited by
the bioflavonoid apigenin |
| Therapeutics |
|
| R. Stephen
Lloyd, Oregon Health & Science University |
Enhanced repair of UV-induced DNA damage by targeting the T4
pyrimidine dimer glycosylase to the nucleus of mammalian cells |
| Philip Stork,
Oregon Health & Science University |
TBA |
| Barbara A. Gilchrest, Boston University School of Medicine |
Using telomere-based DNA damage responses to prevent and treat
skin cancer |
| |
|
| Ervin
Epstein, University of California San Francisco, and Barbara
A. Gilchrest, Boston University School of Medicine |
Break out session strategy and instructions |
| Coffee
Break |
|
| Clinician
break-out sessions* |
Bridging
the basic signaling pathways in skin cancer development to
clinical applications in detection, prognosis and molecular
targeted treatment |
| Clinician
break-out session reports * |
|
| Break |
|
| Salmon Bake on the beach |
|
| |
|
| TUESDAY,
OCTOBER 19 |
|
| Breakfast |
|
| |
|
| Etiology/Interactive Paths |
|
| Rebecca J. Morris, Columbia University |
Isolation, profiling, and fate-determination of keratinocyte
stem cells from the hair follicle bulge |
| Irina Budunova, Northwestern University |
Stem
cells and signaling in skin cancer |
| Aaron P. Jansen, National Cancer Institute |
Transgenic expression in mice of the translation inhibitor,
Pdcd4, demonstrates its tumorigenesis suppressor activity |
| Brandt L. Schneider, Texas Tech UHSC |
The importance of being big |
| Coffee Break |
|
| Molly
Kulesz-Martin, Oregon Health & Science University |
Selective
DNA binding and transactivation by endogenous p53, p63 or p73
isoforms coordinated with apoptosis in response to DNA damage |
| G. Tim Bowden, Arizona Cancer Center |
UVA
mediated signaling pathways in human keratinocytes;
Highlighting
keratinocyte paths for future
|
| G.
Tim Bowden, Arizona Cancer Center |
Highlighting
keratinocyte paths for future |
| Meenhard
Herlyn, University of Pennsylvania |
Highlighting melanoma paths for future |
| |
|
*The
Clinician Breakout sessions will foster interaction in small
groups composed of scientific speakers, clinicians speaking
or attending the meeting, and a cross section of registrants
including Dermatology residents. About 9 groups will be composed
of 12-15 persons each, with a discussion facilitator from
the
Program
Committee assigned to each. After discussion, a leader chosen
by the group will present a short summary for general discussion
among all participants.
|
