October 8-12, 2009 Salishan Spa & Golf Resort, Gleneden Beach, Oregon Genetic-Epigenetic Basis of Skin Diseases Final Program Poster Presentations SID Eugene M. Farber Travel Award Recipients Program Chair: Angela M. Christiano, Ph.D. Columbia University The 2009 Montagna Symposium on the Biology of Skin will examine both genetic and epigenetic aspects of normal skin and of skin diseases such as ectodermal dysplasias, ichthyoses, epidermolysis bullosa, pachyonychia congenita, copper transport diseases, alopecia areata, psoriasis, and atopic dermatitis, as well as melanocyte diseases and cancers of skin and skin appendages. Topics will include genetic basis of both Mendelian and polygenic disorders and epigenetic phenomena, such as miRNAs and chromatin modification. The program will cover genetic and epigenetic roles in development and their relationship to skin cancers and will explore how mouse models of genetic disease and epigenetic phenomena enrich our understanding of genetic susceptibilities, causes and treatments of skin disease. Participants will also discuss strategies for novel therapies for skin diseases, such as siRNAs and drug targets, that have emerged from genetic studies. Preliminary Program: Invited Speakers Thomas Andl, Ph.D. Vanderbilt University miRNAs and skin cancer Allan Balmain, Ph.D., FRSE University of California San Francisco skin cancer susceptibility genes Anne Bowcock, Ph.D. Washington University in St. Louis genetic basis of psoriasis Christophe Cataisson, Ph.D. National Cancer Institute RAS signaling and tumorigenesis Howard Y. Chang, M.D., Ph.D. Stanford University epigenetic control of skin development and disease Angela M. Christiano, Ph.D. Columbia University alopecia areata Andrzej A. Dlugosz, M.D. University of Michigan shh signaling in development and disease Richard Eckert, Ph.D. University of Maryland epigenetic regulation of keratinocytes Ervin Epstein, M.D. Children's Hospital Oakland Research Institute basal cell nevus syndrome Vincent Hearing, Ph.D. National Cancer Institute genetic basis of pigmentary skin diseases Maite Huarte, Ph.D. Broad Institute/Harvard University epigenetics Patrick Iversen, Ph.D. AviBiopharma, Inc. antisense therapeutics Roger L. Kaspar, Ph.D TransDerm, Inc. siRNA therapeutics Maranke Koster, Ph.D. University of Colorado Denver p63 in skin development and ectodermal dysplasias Robert M. Lavker, Ph.D. Northwestern University miRNAs, keratinocytes, and squamous cell carcinoma Michael S. Marks, Ph.D. University of Pennsylvania copper transport diseases and melanosome biogenesis Irwin McLean, Ph.D., DSc, FRSE University of Dundee filaggrin and atopic dermatitis Sarah E. Millar, Ph.D. University of Pennsylvania wnt signaling Maria I. Morasso, Ph.D. National Institute of Arthritis and Musculoskeletal and Skin Disease DLX3 and Tricho-Dento-Osseous syndrome Rebecca Morris, Ph.D. University of Minnesota keratinocyte stem cell regulation Julie Segre, Ph.D. National Human Genome Research Institute transcriptional regulation of epidermal barrier formation Rui Yi, Ph.D. University of Colorado miRNAs and epidermal stem cells Benjamin Yu, M.D., Ph.D. University of California, San Diego RAS and skin development Oral Presentations Selected from Submitted Abstracts Radhika Atit, Ph.D. Case Western Reserve University Skin Deep: Origin and differentiation of dermal cells Vladimir Botchkarev, M.D., Ph.D. Boston University Mechanisms controlling the establishment of tissue-specific chromatin organization in epidermal keratinocytes during skin development Christina de Guzman Strong, Ph.D. NHGRI, NIH The Epidermal Differentiation Complex (EDC): A highly conserved syntenic block harboring regulatory elements including an enhancer in psoriasis-associated LCE3C_LCE3B-del Laura Hansen, Ph.D. Creighton University The epidermal growth factor receptor regulates cell cycle progression at catagen entry Arup Indra, Ph.D. Oregon State University Novel role of Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting proteins 2 (CTIP2) in skin during development Colin Jamora, Ph.D. University of California, San Diego Snail mediated epithelial-leukocytic crosstalk leads to a carcinoma phenotype in the skin Aloysius Klingelhutz, Ph.D. University of Iowa Dyskeratosis Congenita: A human model for studying the role of telomere shortening in the aging of skin Shirley Russell, Ph.D. Vanderbilt University Keloids:A model of epigenetically altered wound healing Stephanie Harkey Shirley, Ph.D. University of Texas M.D. Anderson Cancer Center Regulation of Snail family transcription factors in melanoma Mangalam Subramanian Texas Woman's University HMGN1/N2 Nucleosomal Binding Proteins are involved in the NER-global genome repair subpathway by both histone acetylation-dependent and histone acetylation-independent pathways Carol Trempus, M.S. NIEHS, NIH The T-box transcription factor, Tbx1, abrogates cellular transformation in culture and delays tumor growth in mice